@article{ref1,
title="Study on expression of P53mt protein in skin of patient with arseniasis caused by coal-burning",
journal="Zhonghua Yu Fang Yi Xue Za Zhi",
year="2001",
author="Hu, C. and Zhang, A. and Huang, X.",
volume="35",
number="1",
pages="23-25",
abstract="OBJECTIVE: To study expression of P53mt protein in skin of patient with arseniasis caused by coal-burning. METHODS: According to pathological diagnosis, the patients were divided into carcinoma group (A group, 18 cases), pre-carcinoma group (B group 11 cases) and general pathological change group (C group, 39 cases). Immuno-histochemical technique of two steps was used to detect expression of P53 mt protein. RESULTS: Among A, B and C groups, the positive cell densities of P53mt protein were 38.07 +/- 29.00, 17.16 +/- 15.00 and 4.05 +/- 8.24 respectively, but no positive cell in normal group; there was statistical significance among A, B and C groups (A and C: P < 0.01, A and B: P < 0.01, B and C: P < 0.05); positive percentages of A, B and C groups were 88.89%, 72.73% and 25.64% (A and C: P < 0.01; B and C: P < 0.05), respectively, for difference of grade constitution, there was statistical significance (P < 0.01) among three groups; grade II and III made up 38.89% in A group, but 9.09% in B group and 2.56% in C group. CONCLUSIONS: P53mt gene play a certain role in the development of skin cancer from arseniasis caused by coal-burning; the detection of P53mt protein can show whether pathological changes of skin due to the disease is malignant or benign.<p /><p>Language: zh</p>",
language="zh",
issn="0253-9624",
doi="",
url="http://dx.doi.org/"
}