@article{ref1,
title="Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers",
journal="Experimental and clinical psychopharmacology",
year="2001",
author="Rush, C. R. and Baker, R. W.",
volume="9",
number="1",
pages="59-73",
abstract="Six human participants with recent histories of cocaine use were trained to discriminate 200 mg oral cocaine hydrochloride. A range of doses of oral cocaine (50-300 mg), methylphenidate (15-90 mg), triazolam (0.125-0.75 mg), and placebo were then tested to determine whether they shared discriminative-stimulus and participant-rated effects with 200 mg cocaine. Cocaine and methylphenidate dose-dependently increased cocaine-appropriate responding, produced prototypical stimulant-like participant-rated drug effects (e.g., increased participant ratings of Drug Liking), and increased heart rate and blood pressure. Triazolam produced low levels of cocaine-appropriate responding and impaired performance. Thus, consistent with previous studies, humans can reliably discriminate oral cocaine. Consistent with in vivo behavioral neuropharmacological data, the discriminative-stimulus, participant-rated, and physiological effects of oral cocaine and methylphenidate were similar.<p /><p>Language: en</p>",
language="en",
issn="1064-1297",
doi="",
url="http://dx.doi.org/"
}