@article{ref1,
title="Acute renal failure following deferoxamine overdose",
journal="Pediatric nephrology",
year="2003",
author="Prasannan, Latha and Flynn, Joseph T. and Levine, John E.",
volume="18",
number="3",
pages="283-285",
abstract="A 17-year-old patient with sickle cell-beta thalassemia undergoing treatment with home iron chelation therapy inadvertently received ten times the recommended dose of intravenous deferoxamine. Acute renal failure (ARF) developed within hours. Immediate treatment with high-efficiency hemodialysis resulted in the prompt return of renal function after only one hemodialysis session. No long-term nephrotoxic effects of the deferoxamine overdose developed after more than 1 year of follow-up. Children with sickle cell disease who are on intravenous deferoxamine and their parents should be cautioned about the possibility of ARF with overdose due to malfunction of the pump and/or inadequate monitoring during treatment. ARF, should it occur in such children, appears to respond well to treatment with high-efficiency hemodialysis.<p /><p>Language: en</p>",
language="en",
issn="0931-041X",
doi="10.1007/s00467-002-1051-7",
url="http://dx.doi.org/10.1007/s00467-002-1051-7"
}