@article{ref1,
title="Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress",
journal="Biological psychiatry",
year="2005",
author="Richell, Rebecca A. and Deakin, J. F. William and Anderson, Ian M.",
volume="57",
number="3",
pages="295-300",
abstract="BACKGROUND: Previous research provides evidence linking serotonin (5-hydroxytryptamine, 5-HT) with stress and depression. The controllable/uncontrollable (C/UC) stress paradigm aims to generate a state/condition, namely a feeling of lack of control in the context of a stressor, which might be an important factor in precipitating a negative mood state. Acute tryptophan depletion (ATD) is a technique that produces a decrease in central 5-HT levels in vivo. This study investigated the role of 5-HT in the behavioral response to a C/UC stress paradigm with ATD. METHODS: Healthy adult volunteers were randomly assigned to receive either a TRP-supplemented (n = 15) or TRP-deficient (n = 13) amino acid drink. At 5 hours postdrink, volunteers were subjected to sessions of controllable and uncontrollable noise stress (100-dB white noise). Subjective ratings of mood were obtained before and after the interventions. RESULTS: Participants who received the tryptophan-depleting drink had greater self-report ratings of negative mood on visual analogue scales and the Profile of Mood States after the uncontrollable stress than did participants who received the balanced drink. CONCLUSIONS: The results suggest that 5-HT might play a role in providing resilience to uncontrollable stress. Additional studies with specific 5-HT pharmacologic probes will further clarify the results.<p /><p>Language: en</p>",
language="en",
issn="0006-3223",
doi="10.1016/j.biopsych.2004.10.010",
url="http://dx.doi.org/10.1016/j.biopsych.2004.10.010"
}