@article{ref1,
title="Sub-therapeutic doses in the treatment of depression: the implications of starting low and going slow",
journal="Journal of Mind-Body Regulation",
year="2011",
author="de Jong, Veronica and Raz, Amir",
volume="1",
number="2",
pages="73-84",
abstract="Psychiatrists who opt to treat depression with antidepressant medication typically &quot;start low and go slow&quot; - initially prescribing modest doses and then gradually increasing them. General practitioners, moreover, tend to prescribe low, even sub-therapeutic, maintenance doses of antidepressants. Indeed, some patients report clinical improvements even while taking extremely low-dose medication. Controversial meta-analytic findings suggest a negligible clinical benefit of antidepressants over placebos for the treatment of mild-to-moderate depression, although both interventions improve depression ratings compared to no-treatment. Do sub-therapeutic doses of antidepressants provide a treatment prospect for healthcare professionals who wish to use placebo-like treatments for depression? In this paper, we use results from psychiatrist interviews to explore the vagaries of sub-therapeutic doses and shed light on whether they have a place in the armamentarium of the modern clinician.<p />",
language="",
issn="1925-1688",
doi="",
url="http://dx.doi.org/"
}