@article{ref1,
title="Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury",
journal="Journal of critical care",
year="2012",
author="Jin, Yong and Li, Bo-You and Qiu, Ling-Li and Ling, Yuan-Ren and Bai, Zhi-Qiang",
volume="27",
number="5",
pages="527.e1-5276",
abstract="PURPOSE: Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. METHODS: One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA. RESULTS: Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score. CONCLUSIONS: Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.<p /> <p>Language: en</p>",
language="en",
issn="0883-9441",
doi="10.1016/j.jcrc.2012.01.002",
url="http://dx.doi.org/10.1016/j.jcrc.2012.01.002"
}