@article{ref1,
title="Responses of microglia and neural progenitors to mechanical brain injury",
journal="Neuroreport",
year="1999",
author="Tzeng, S. F. and Wu, J. P.",
volume="10",
number="11",
pages="2287-2292",
abstract="Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infiltration along with nuclear factor kappa B (NF kappa B)/p65 activation at the lesion site. Most NF kappa B/p65+ cells displayed a phagocytic morphology. Under these conditions, profound cell apoptosis took place in the injured corpus callosum, but not in the subventricular/ventricular zone (SVZ/VZ). The SVZ/VZ-derived neural progenitors in both injected and non-injected contralateral hemispheres showed strong BrdU immunostaining, indicating that SVZ/VZ-derived neural progenitors of both hemispheres may undergo DNA synthesis in response to unilateral brain injury.<p /><p>Language: en</p>",
language="en",
issn="0959-4965",
doi="",
url="http://dx.doi.org/"
}