@article{ref1,
title="Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale",
journal="Alcohol",
year="2000",
author="Malcolm, R. and Herron, J. E. and Anton, Raymond F. and Roberts, Julian V. and Moore, J.",
volume="20",
number="2",
pages="181-185",
abstract="Research has demonstrated a relationship between the number of previous alcohol detoxifications and increased severity of the alcohol withdrawal syndrome (AWS) that is hypothesized to be similar to an electrophysiologic &quot;kindling process.&quot; Application of a &quot;kindling&quot; model to AWS suggests that neuroadaptation of the central nervous system to repeated detoxifications may also cause neurobehavioral alterations that may affect &quot;craving.&quot; This study examined craving as assessed by the Obsessive Compulsive Drinking Scale (OCDS) in 67 adult outpatients meeting DSM-IV criteria (American Psychiatric Association, 1994) for alcohol dependence and AWS having either < 2 and > or = 2 previous detoxifications. Results of ANCOVA revealed that patients with > or = 2 previous detoxifications had higher scores on a scale that measures obsessive thoughts about alcohol, drinking urges and behaviors, and a composite of these scores after controlling for alcohol dependence severity, depressive symptoms and number of drinks 2 weeks prior to the study. Findings emphasize the need to address craving and other psychological variables with respect to treatment of AWS.<p /><p>Language: en</p>",
language="en",
issn="0741-8329",
doi="",
url="http://dx.doi.org/"
}