@article{ref1,
title="Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema",
journal="Annals of neurology",
year="2002",
author="Lynch, John R. and Pineda, Jose A. and Morgan, Duncan and Zhang, Lin and Warner, David S. and Benveniste, Helen and Laskowitz, Daniel T.",
volume="51",
number="1",
pages="113-117",
abstract="Apolipoprotein E has been implicated in modifying neurological outcome after traumatic brain injury, although the mechanisms by which this occurs remain poorly defined. To investigate the role of endogenous apolipoprotein E following acute brain injury, noninvasive magnetic resonance imaging was performed on anesthetized mice following closed head injury. Effacement of the lateral ventricle was used as a radiographic surrogate for cerebral edema. At 24 hours following injury, apolipoprotein E-deficient animals had a greater degree of cerebral edema as compared to matched controls. In addition, the brains of apolipoprotein E-deficient animals had a significantly greater upregulation of tissue necrosis factor alpha messenger ribonucleic acid as compared to controls as early as 1-hr post injury. Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury.<p /><p>Language: en</p>",
language="en",
issn="0364-5134",
doi="",
url="http://dx.doi.org/"
}