@article{ref1,
title="Influence of process variables on release properties of paracetamol tablets",
journal="Acta pharmaceutica",
year="2007",
author="Alebiowu, Gbenga and Itiola, Oludele",
volume="57",
number="1",
pages="73-86",
abstract="A 2 3 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration ( c ) and relative density of tablet ( d ) on the disintegration time ( DT ) and dissolution times, t 1 , t 50 and t 90 , of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e. , N, c and d. In general, the most common ranking of the individual effects on DT , t 1 , t 50 and t 90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N- c > c-d > N- d for all formulations. The results generally showed that c can considerably affect DT, t 1 , t 50 and t 90 of the tablets.<p />",
language="",
issn="1330-0075",
doi="10.2478/v10007-007-0006-8",
url="http://dx.doi.org/10.2478/v10007-007-0006-8"
}