@article{ref1,
title="Receptor-targeting mechanisms of pain-causing toxins: How ow?",
journal="Toxicon: Journal of the International Society on Toxinology",
year="2012",
author="Bohlen, Christopher J. and Julius, David",
volume="60",
number="3",
pages="254-264",
abstract="Venoms often target vital processes to cause paralysis or death, but many types of venom also elicit notoriously intense pain. While these pain-producing effects can result as a byproduct of generalized tissue trauma, there are now multiple examples of venom-derived toxins that target somatosensory nerve terminals in order to activate nociceptive (pain-sensing) neural pathways. Intriguingly, investigation of the venom components that are responsible for evoking pain has revealed novel roles and/or configurations of well-studied toxin motifs. This review serves to highlight pain-producing toxins that target the capsaicin receptor, TRPV1, or members of the acid-sensing ion channel family, and to discuss the utility of venom-derived multivalent and multimeric complexes.<p /> <p>Language: en</p>",
language="en",
issn="0041-0101",
doi="10.1016/j.toxicon.2012.04.336",
url="http://dx.doi.org/10.1016/j.toxicon.2012.04.336"
}