@article{ref1,
title="Renal consequences of immobilisation in children with fractured femurs",
journal="Acta paediatrica Scandinavica",
year="1990",
author="Andrews, P. I. and Rosenberg, A. R.",
volume="79",
number="3",
pages="311-315",
abstract="Parameters of renal function and calcium homeostasis were studied in 8 children, immobilised for 5-9 weeks with fractured femurs, weekly during immobilisation and fourth weekly following mobilisation until all parameters returned to normal. During immobilisation 1 patient became hypercalcaemic, but all showed an increase in serum calcium and all developed hypercalciuria. During immobilisation all showed diminished urine osomolality after a 12-hour fast (mean 591 +/- 133 mOsm/kg) which improved 4-39 weeks after mobilisation (mean 973 +/- 87 mOsm/kg). Serum creatinine, urinary beta-2-microglobulin and renal ultrasound appearances were all normal. An inverse relationship, R = -0.70, was demonstrated between serum calcium and fasting urine osmolality during immobilisation. Three patients showed diminished urinary concentrating ability beyond 4 weeks after mobilisation. For 1 patient this defect persisted for 8 months and glomerular filtration rate was diminished 9 months after mobilisation, raising the possibility of long term renal damage in immobilised patients.<p /><p>Language: en</p>",
language="en",
issn="0001-656X",
doi="",
url="http://dx.doi.org/"
}