@article{ref1,
title="Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease",
journal="American journal of psychiatry",
year="1990",
author="Pearlson, Godfrey D. and Ross, C. A. and Lohr, W. D. and Rovner, B. W. and Chase, G. A. and Folstein, M. F.",
volume="147",
number="4",
pages="452-456",
abstract="For each of 41 index patients with probable Alzheimer's disease and a first episode of major depression and 71 nondepressed Alzheimer's disease patients, two first-degree relatives were interviewed by a rater blind to presence or absence of depression in the proband. The depressed patients had significantly more first- and second-degree relatives with depression than did control subjects. The lifetime risk for major depression, adjusted for differences in age distribution, was significantly greater in first-degree relatives of index patients, suggesting that depression in Alzheimer's disease is genetically related to primary affective disorder. Alzheimer's disease may be useful for studying aspects of depressive pathophysiology.<p /><p>Language: en</p>",
language="en",
issn="0002-953X",
doi="",
url="http://dx.doi.org/"
}