@article{ref1,
title="Deep brain stimulation for aggressive and disruptive behaviour",
journal="World neurosurgery",
year="2013",
author="Franzini, Angelo and Broggi, Giovanni and Cordella, Roberto and Dones, Ivano and Messina, Giuseppe",
volume="80",
number="3-4",
pages="S29.e11-S29.e14",
abstract="OBJECTIVE: To describe our Institutional experience with Deep Brain Stimulation ( DBS) employed for treatment of aggressive and disruptive behaviour refractory to conservative treatments METHODS: With stereotactic methodology and under general anaesthesia, 7 patients ( from 2002 to 2010) were submitted to DBS of posterior hypothalamic ( pHyp) region, bilaterally, and with the aid of intraoperative microrecording RESULTS: 6 out of 7 patients presented a clear-cut improvement in the aggressive and disruptive bouts, with subsequent simplification of familiar management CONCLUSIONS: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behaviour coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.<p /> <p>Language: en</p>",
language="en",
issn="1878-8750",
doi="10.1016/j.wneu.2012.06.038",
url="http://dx.doi.org/10.1016/j.wneu.2012.06.038"
}