@article{ref1,
title="Assessing the efficacy of 2 screening measures for depression in people with epilepsy",
journal="Neurology",
year="2012",
author="Gandy, Milena and Sharpe, Louise and Nicholson Perry, Kathryn and Miller, Laurie and Thayer, Zoe and Boserio, Janet and Mohamed, Armin",
volume="79",
number="4",
pages="371-375",
abstract="OBJECTIVES:The aim of this study was to compare the efficacy of the Neurological Depressive Disorders Inventory for Epilepsy (NDDI-E) and the depression component of the Hospital Anxiety Depression Scale (HADS-D) for identifying depression and suicide risk in adults with epilepsy. METHODS:A total of 147 (87 female [59%]) outpatients attending a tertiary epilepsy center in Sydney Australia completed the NDDI-E and HADS-D. They then completed the depression and suicide sections of the Mini International Neuropsychiatric Inventory (MINI) with a clinician blind to symptom measure scores. Receiver operator characteristic analysis was performed for the clinical cutoff scores for depression on the NDDI-E ≥15 and HADS-D ≥8 to identify MINI-determined depression and suicidality. RESULTS:The NDDI-E indicated strong sensitivity (84%) and acceptable specificity (78%), whereas the HADS-D had poor sensitivity (42%) but good specificity (97%) for identifying depression. For identifying suicide risk, the NDDI-E indicated strong sensitivity (81%) and reasonable specificity (66%), whereas the HADS-D had poor sensitivity (43%) but acceptable specificity (90%). Area under the curve comparisons for these measures were not significant. CONCLUSION:In clinical practice, it is essential that screening measures have the highest possible sensitivity values to limit the chances of false-negative results. In accordance with these guidelines, the NDDI-E was a superior screening measure compared with the HADS-D. Our results demonstrate the efficacy of the NDDI-E for identifying both major and minor depression and serious suicide risk. The poor sensitivity of the HADS-D suggests that it should not be used as a screen for depression or suicidality in adults with epilepsy.<p /> <p>Language: en</p>",
language="en",
issn="0028-3878",
doi="10.1212/WNL.0b013e318260cbfc",
url="http://dx.doi.org/10.1212/WNL.0b013e318260cbfc"
}