@article{ref1,
title="Possible genetic association between vasopressin receptor 1B and child aggression",
journal="Psychiatry research",
year="2012",
author="Zai, Clement C. and Muir, Katherine E. and Nowrouzi, Behdin and Shaikh, Sajid A. and Choi, Esther and Berall, Laura and Trépanier, Marc-Olivier and Beitchman, Joseph H. and Kennedy, James L.",
volume="200",
number="2-3",
pages="784-788",
abstract="Background: Studies on animal models have implicated arginine vasopressin signalling pathway in aggressive behaviour. The role of arginine vasopressin in childhood onset aggression is unclear. Methods: We investigated 11 single-nucleotide polymorphisms in the genes coding for arginine vasopressin and its receptors in our sample of 177 aggressive child cases paired with adult controls matched for sex and ethnicity. Results: We found the non-synonymous polymorphism AVPR1B_rs35369693 to be associated with child aggression in our sample (P=0.007). We also found two-marker haplotype window containing AVPR1B_rs35369693 and AVPR1B_rs28676508 to be associated (P=0.003). The haplotype findings survived multiple-testing adjusted significance threshold of 0.0063. Conclusions: This is the first report of a genetic association between vasopressin receptor 1B and child aggression. Replication in independent samples are required to confirm these findings.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2012.07.031",
url="http://dx.doi.org/10.1016/j.psychres.2012.07.031"
}