@article{ref1,
title="The association between recipient alcohol dependency and long-term graft and recipient survival",
journal="Nephrology, dialysis, transplantation",
year="2007",
author="Gueye, Abdou S. and Chelamcharla, Madhukar and Baird, Bradley C. and Nguyen, Cuong and Tang, Hongying and Barenbaum, Anna L. and Koford, James K. and Shihab, Fuad and Goldfarb-Rumyantzev, Alexander S.",
volume="22",
number="3",
pages="891-898",
abstract="BACKGROUND: The causative role of alcohol consumption in renal disease is controversial, and its effect on renal graft and recipient survival has not been previously studied. METHODS: We analysed the association between pre-transplant [at the time of end-stage renal disease (ESRD) onset] alcohol dependency and renal graft and recipient survival. The United States Renal Data System (USRDS) records of kidney transplant recipients 18 years or older transplanted between 1 January 1995 and 31 December 2002 were examined. We used Kaplan-Meier analysis and Cox regression models adjusted for covariates to analyse the association between pre-transplant alcohol dependency and graft and recipient survival. RESULTS: In an entire study cohort of 60 523, we identified 425 patients with a history of alcohol dependency. Using Cox models, alcohol dependency was found to be associated with increased risk of death-censored graft failure [hazard ratio (HR) 1.38, P < 0.05] and increased risk of transplant recipient death (HR 1.56, P < 0.001). Subgroup analysis demonstrated an association of alcohol-dependency with recipient survival and death-censored graft survival in males (but not in females), and in both white and non-white racial subgroups. CONCLUSIONS: We concluded that alcohol dependency at the time of ESRD onset is a risk factor for renal graft failure and recipient death.<p /><p>Language: en</p>",
language="en",
issn="0931-0509",
doi="10.1093/ndt/gfl689",
url="http://dx.doi.org/10.1093/ndt/gfl689"
}