@article{ref1,
title="Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS)",
journal="Journal of Mass Spectrometry",
year="2012",
author="Jürschik, Simone and Agarwal, Bishu and Kassebacher, Thomas and Sulzer, Philipp and Mayhew, Christopher A. and Märk, Tilmann D.",
volume="47",
number="9",
pages="1092-1097",
abstract="In this work, we illustrate the application of proton transfer reaction mass spectrometry (PTR-MS) in the field of food and drink safety. We present proof-of-principle measurements of four different drinks (water, tea, red wine and white wine) each spiked separately with four different date rape drugs (chloral hydrate, tricholorethanol, γ-butyrolactone and butanediol). At first, the ideal PTR-MS operating conditions (reduced electric field strength and monitoring the most abundant [fragment] ion) for detection of the drugs were determined utilizing a time-of-flight-based PTR-MS instrument. We then dissolved small quantities of the drugs (below the activation threshold for effects on humans) into the various types of drinks and detected them using a quadrupole-based PTR-MS instrument via two different sampling methods: (1) dynamic headspace sampling and (2) direct liquid injection. Both methods have their advantages and drawbacks. Only with dynamic headspace sampling can rape drug contaminations be detected within a timeframe of seconds, and therefore, this method is the most promising use of PTR-MS as a fast, sensitive and selective monitor for the detection of food and drink contamination. Copyright © 2012 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>",
language="en",
issn="1076-5174",
doi="10.1002/jms.2993",
url="http://dx.doi.org/10.1002/jms.2993"
}