@article{ref1,
title="Fatal doxepin intoxication - Suicide or slow gradual intoxication?",
journal="Forensic science international",
year="2013",
author="Neukamm, M. A. and Vogt, S. and Hermanns-Clausen, M. and Naue, J. and Thierauf, A. and Auwärter, V.",
volume="227",
number="1-3",
pages="82-84",
abstract="The differentiation of intoxication courses is one of the most difficult challenges for forensic pathologists and toxicologists. The case of a 52-year-old female inpatient of a psychiatric clinic with multiple medications who died from doxepin intoxication is reported. Concentrations of doxepin metabolites and isomers, pharmacokinetic modelling and genotyping of the doxepin-metabolizing cytochrome P450 (CYP) enzymes led to the following conclusion: the lethal doxepin concentration of 2100ng/mL was more likely to have been reached due to drug interactions and genetic peculiarities leading to a reduction of the metabolic capacity and not by an acute (suicidal) overdose.<p /> <p>Language: en</p>",
language="en",
issn="0379-0738",
doi="10.1016/j.forsciint.2012.08.050",
url="http://dx.doi.org/10.1016/j.forsciint.2012.08.050"
}