@article{ref1,
title="Risk of epilepsy after traumatic brain injury: a retrospective population-based cohort study",
journal="Journal of neurology, neurosurgery, and psychiatry",
year="2013",
author="Yeh, Chun-Chieh and Chen, Ta-Liang and Hu, Chaur-Jong and Chiu, Wen-Ta and Liao, Chien-Chang",
volume="84",
number="4",
pages="441-445",
abstract="OBJECTIVE: To investigate the associated risk of epilepsy after traumatic brain injury (TBI) in a population-based retrospective cohort study. METHODS: Using Taiwan's National Health Insurance Research Database of reimbursement claims, we conducted a retrospective cohort study of 19 336 TBI patients and 540 322 non-TBI participants aged ≥15 years as reference group. Data on newly developed epilepsy after TBI with 5-8 years' follow-up during 2000 to 2008 were collected. HRs and 95% CIs for the risk of epilepsy associated with TBI were analysed with multivariate Cox proportional hazards regressions. RESULTS: Compared with the non-TBI cohort, the adjusted HRs of developing epilepsy among TBI patients with skull fracture, severe or mild brain injury were 10.6 (95% CI 7.14 to 15.8), 5.05 (95% CI 4.40 to 5.79) and 3.02 (95% CI 2.42 to 3.77), respectively. During follow-up, men exhibited higher risks of post-TBI epilepsy. Patients who had mixed types of cerebral haemorrhage were at the highest risk of epilepsy compared with the non-TBI cohort (HR 7.83, 95% CI 4.69 to 13.0). The risk of post-TBI epilepsy was highest within the first year after TBI (HR 38.2, 95% CI 21.7 to 67.0). CONCLUSIONS: The risk of epilepsy after TBI varied by patient gender, age, latent interval and complexity of TBI. Integrated care for early identification and treatment of post-trauma epilepsy were crucial for TBI patients.<p /> <p>Language: en</p>",
language="en",
issn="0022-3050",
doi="10.1136/jnnp-2012-302547",
url="http://dx.doi.org/10.1136/jnnp-2012-302547"
}