@article{ref1,
title="Risk of injurious road traffic crash after prescription of antidepressants",
journal="Injury prevention",
year="2012",
author="Lagarde, E. and Queinec, R. and Philip, Pierre and Gadegbeku, B. and Delorme, B. and Moore, N. and Suissa, S. and Salmi, Louis-Rachid and Orriols, L.",
volume="18",
number="Suppl 1",
pages="A187-A187",
abstract="Background Antidepressants are commonly used worldwide. Experimental studies have suggested that antidepressants may impair driving abilities.  Aims/Objectives/Purpose The study aims to estimate the risk of road traffic crash associated with prescription of antidepressants.  Methods Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. A case-control analysis comparing 34 896 responsible versus 37 789 non-responsible drivers was conducted. Case-crossover analysis was performed to investigate the acute effect of medicine exposure.  Results/Outcomes 72 685 drivers identified by their national healthcare number, involved in an injurious crash in France over the July 2005 to May 2008 period, were included. 2936 drivers (4.0%) were exposed to at least one antidepressant on the day of the crash. The results showed a significant association between the risk of being responsible for a crash and prescription of antidepressants (OR=1.34 (1.22 to 1.47)). The case-crossover analysis showed no association with treatment prescription but the risk of road traffic crash increased after an initiation of an antidepressant treatment (OR=1.49 (1.24 to 1.79)) and after a change in antidepressant treatment (OR=1.32 (1.09 to 1.60)).  Significance/Contribution to the Field Patients and prescribers should be warned about the risk of crash during periods of antidepressant medication and particularly high vulnerability periods such as those when a treatment is initiated or modified.   This is an abstract of a presentation at Safety 2012, the 11th World Conference on Injury Prevention and Safety Promotion, 1-4 October 2012, Michael Fowler Center, Wellington, New Zealand. Full text does not seem to be available for this abstract. <p />",
language="en",
issn="1353-8047",
doi="10.1136/injuryprev-2012-040590r.3",
url="http://dx.doi.org/10.1136/injuryprev-2012-040590r.3"
}