@article{ref1,
title="Follow-up study of two-year-olds born at very low gestational age in Estonia",
journal="Acta paediatrica",
year="2013",
author="Toome, Liis and Varendi, Heili and Männamaa, Mairi and Vals, Mari-Anne and Tänavsuu, Triinu and Kolk, Anneli",
volume="102",
number="3",
pages="300-307",
abstract="AIM: To study very low gestational age (VLGA, <32 weeks) infants at two years of age and to identify the predictors of adverse outcomes. METHODS: A population-based cohort of 155 surviving VLGA infants born in Estonia in 2007 was followed up and compared with a matched full-term control group. A logistic regression model was used to test associations between risk factors and adverse outcomes. RESULTS: No impairment was found in 60% of the VLGA infants. Neurodevelopmental impairment was noted in 12% of VLGA infants, with 8% of the infants affected by cerebral palsy without independent walking, 5% with cognitive delay, 10% with language delay, and 1% with hearing impairment. The differences between preterm and full-term infants in terms of the mean Cognitive, Language, and Motor Composite Scores assessed using the Bayley-III scales were in excess of 0.5 SD. Somatic growth delay was a significant problem among preterm infants. The existence of severe neonatal cerebral lesions was the most significant predictor of adverse outcomes. CONCLUSION: In all domains studied, adverse conditions were more prevalent among VLGA infants than among the full-term control group. Efforts to reduce neonatal morbidity in preterm infants should be a key priority for health care in Estonia. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.<p /> <p>Language: en</p>",
language="en",
issn="0803-5253",
doi="10.1111/apa.12091",
url="http://dx.doi.org/10.1111/apa.12091"
}