@article{ref1,
title="Levothyroxine poisoning: clinical manifestations and therapeutic management",
journal="Anales de Medicina Interna",
year="2004",
author="de Luis, D. A. and Abad, L. and Aller, R. and González-Sagrado, M. and Dueñas, A.",
volume="21",
number="1",
pages="39-41",
abstract="Intoxication with L-tyroxine has a low prevalence, high prevalence is observed in pediatric age. Toxic dose is unclear, asymptomatic patients have been observed with doses under 5 mg. Systems with high prevalence of symptoms are cardiovascular system, sympathetic nervous system and gastrointestinal tube. Symptoms could appear from hours to days after ingestion. Early hours after L-tyroxine ingestion, levels of T4 and T3 are not related with severity. However, monitoring seric levels is necessary to lead therapeutic approach and to give a prognosis. Daily determinations of T3, T4 and TSH are necessaries. Determinations of temperature, arterial pressure and blood heart rate are needed to control complications. Beta-blockers and intestinal decontamination drugs are used during therapeutic approach. Other therapeutic options are iopanoic acid and propylthiouracil. In summary, intoxication with L-tyroxine could be a severe situation. It is necessary to describe therapeutic protocols in this entity.<p /><p>Language: es</p>",
language="es",
issn="0212-7199",
doi="",
url="http://dx.doi.org/"
}