@article{ref1,
title="Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence",
journal="Journal of Adolescent Health",
year="2013",
author="Heinzerling, Keith G. and Gadzhyan, Janette and van Oudheusden, Henry and Rodriguez, Felipe and McCracken, James and Shoptaw, Steven",
volume="52",
number="4",
pages="502-505",
abstract="PURPOSE: To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. METHODS: Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. RESULTS: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively. CONCLUSIONS: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.<p /> <p>Language: en</p>",
language="en",
issn="1054-139X",
doi="10.1016/j.jadohealth.2012.10.275",
url="http://dx.doi.org/10.1016/j.jadohealth.2012.10.275"
}