@article{ref1,
title="Bilateral acute necrosis of the globi pallidi and rhabdomyolysis due to combined methadone and benzodiazepine toxicity",
journal="American journal of forensic medicine and pathology",
year="2013",
author="Corliss, Robert F. and Mandal, Rakesh and Soriano, Benjamin J.",
volume="34",
number="1",
pages="1-4",
abstract="Methadone continues to be a widely used maintenance therapy for opiate dependence. However, methadone-related deaths have been reported frequently for over 4 decades now. Anoxic brain injury with pulmonary edema secondary to respiratory depression is the recognized mechanism of methadone death, although pathological intracranial findings are rarely described in methadone deaths. A selective area of brain injury has never been reported with methadone use. We present a case of a 23-year-old man who had acute necrosis of the bilateral globi pallidi in the brain and systemic rhabdomyolysis after ingesting methadone and nasally insufflating alprazolam. We also present a review of the literature on deaths following opioid use and associated brain injury.<p /> <p>Language: en</p>",
language="en",
issn="0195-7910",
doi="10.1097/PAF.0b013e31823a8b1e",
url="http://dx.doi.org/10.1097/PAF.0b013e31823a8b1e"
}