@article{ref1,
title="The role of cortisol and psychopathy in the cycle of violence",
journal="Psychopharmacology",
year="2013",
author="Gowin, Joshua L. and Green, Charles E. and Alcorn, Joseph L. and Swann, Alan C. and Moeller, F. Gerard and Lane, Scott D.",
volume="227",
number="4",
pages="661-672",
abstract="RATIONALE: Child abuse and neglect are universal risk factors for delinquency, violence, and aggression; this phenomenon is known as the cycle of violence. Additional factors-psychopathy, impulsiveness, and disruptions in the hypothalamic-pituitary-adrenal (HPA) axis-play a role in aggressive behavior but have rarely been examined in the same conceptual and experimental framework. OBJECTIVES: We sought to examine the above-mentioned risk factors for aggression in a prospective study employing psychopharmacologic and psychometric techniques. METHODS: Sixty-seven adult participants were given an acute dose of 20 mg cortisol in a placebo-controlled, within-subject, counter-balanced dosing design. Salivary cortisol was measured at baseline and at regular intervals across a 5 h testing period. Following dosing, state-aggressive behavior was measured by a laboratory task, the Point-Subtraction Aggression Paradigm. History of child abuse/neglect, psychopathy, impulsivity, and a trait measure of aggression were assessed through self-report questionnaires. RESULTS: Using multiple regression, a model including abuse/neglect, psychopathy, impulsivity, and baseline cortisol explained 58 % of the variance in trait aggression and 26 % of the variance in state aggression. Abuse/neglect predicted diminished HPA-axis reactivity and HPA-axis reactivity showed a trend toward predicting state and trait aggression, although it was not a significant mediating variable between abuse/neglect and aggression. CONCLUSIONS: The results indicate that child maltreatment, psychopathy and HPA-axis reactivity interact to provide a confluence over aggressive behavior, and intervention efforts need to consider all these factors.<p /> <p>Language: en</p>",
language="en",
issn="0033-3158",
doi="10.1007/s00213-013-2992-1",
url="http://dx.doi.org/10.1007/s00213-013-2992-1"
}