@article{ref1,
title="Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S 100",
journal="Unfallchirurg",
year="2004",
author="Biberthaler, P. and Mussack, T. and Kanz, K-G and Linsenmaier, U. and Pfeifer, K-j and Mutschler, W. and Jochum, M.",
volume="107",
number="3",
pages="197-202",
abstract="The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S 100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S 100 in these CCT+ patients was significantly increased (0.31 microg/l) compared to the healthy control group (0.04 microg/l) as well as to the CCT-negative patients (0.08 microg/l). The ELECSYS S100 system allows a rapid, valid, and reproducible assessment of S 100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently underway to confirm the results of our pilot study.<p /><p>Language: de</p>",
language="de",
issn="0177-5537",
doi="10.1007/s00113-004-0730-1",
url="http://dx.doi.org/10.1007/s00113-004-0730-1"
}