@article{ref1,
title="Acamprosate in alcohol dependence: a randomized controlled efficacy study in a standard clinical setting",
journal="Journal of studies on alcohol",
year="2004",
author="Baltieri, Danilo Antonio and de Andrade, Arthur Guerra",
volume="65",
number="1",
pages="136-139",
abstract="OBJECTIVE: This study was undertaken to evaluate the efficacy and safety of acamprosate in the treatment of alcohol dependence. METHOD: The investigation was a double-blind, placebo-controlled, 24-week study carried out at the University of São Paulo, Brazil. The sample comprised 75 patients, 18-60 years of age, with an International Classification of Diseases (ICD-10) diagnosis of alcohol dependence. After a 1-week detoxification period the patients were randomly divided into two groups: the first received acamprosate (1.998 mg/day) and the second received placebo. After the first 12 weeks, the patients continued follow-up for a similar length of time without medication. The main outcome measures were relapse rates, side effects and time to first relapse. RESULTS: On an intention-to-treat basis, the Kaplan-Meier survival curve showed an advantage in relapse rates for acamprosate over placebo (log-rank test, p = .02), and acamprosate was well tolerated. CONCLUSIONS: Acamprosate seems to be an effective treatment for alcohol dependence in a Brazilian population.<p /><p>Language: en</p>",
language="en",
issn="0096-882X",
doi="",
url="http://dx.doi.org/"
}