@article{ref1,
title="Correlation of risk-taking propensity with cross-frequency phase-amplitude coupling in the resting EEG",
journal="Clinical neurophysiology",
year="2013",
author="Lee, Jaewon and Jeong, Jaeseung",
volume="124",
number="11",
pages="2172-2180",
abstract="OBJECTIVE: Recent evidence has suggested that the weak inhibitory influence of the prefrontal cortex on the subcortical structures may be responsible for risk-taking behaviour. The aim was to determine the possibility that this weakness in top-down control is reflected in changes in the cross-frequency phase-amplitude coupling (CFPAC) in the electroencephalography (EEG). METHODS: Nineteen-channel EEGs were recorded from 50 healthy volunteers with their eyes closed before risk-taking propensity was assessed by behavioural measures, the domain-specific risk-taking (DOSPERT) scale and the Barrett impulsiveness scale (BIS). Correlation analyses between the CFPACs and the behavioural measures were performed. RESULTS: The CFPACs were negatively correlated with the risk-taking DOSPERT and BIS scores in frontal (Fp2) and centro-parietal (C3, C4 and P4) regions. By contrast, the CFPACs were positively correlated with the risk-taking DOSPERT and BIS scores in the right hemisphere (T8 and P8). CONCLUSIONS: We suggest that frequent risk-taking behaviour is closely associated with the reduced interference of the cortical control network on the reward-oriented system. The CFPAC, which reflects the degree of interactions among functional systems, provides information about an individual's risk-taking propensity. SIGNIFICANCE: The CFPAC may be a useful neurophysiological indicator of an individual's tendency towards risk-taking behaviours, which thus potentially contributes to evaluating the severity of the psychiatric diseases exhibiting abnormal risk-taking behaviours.<p /> <p>Language: en</p>",
language="en",
issn="1388-2457",
doi="10.1016/j.clinph.2013.05.007",
url="http://dx.doi.org/10.1016/j.clinph.2013.05.007"
}