@article{ref1,
title="Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003",
journal="Birth defects research. Part A, clinical and molecular teratology",
year="2013",
author="Sauber-Schatz, Erin K. and Bodnar, Lisa M. and Weiss, Harold B. and Wilson, John W. and Pearlman, Mark D. and Markovic, Nina",
volume="97",
number="10",
pages="641-648",
abstract="BACKGROUND: Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system-related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy. METHODS: Through a case-control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999-2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy. RESULTS: Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63-1.56 and 2.44; 95% confidence interval, 1.08-5.53 among breech presentation infants. Probabilistic bias analysis supported these findings. CONCLUSION: No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc.<p /> <p>Language: en</p>",
language="en",
issn="1542-0752",
doi="10.1002/bdra.23143",
url="http://dx.doi.org/10.1002/bdra.23143"
}