@article{ref1,
title="In vitro comparison of enzymatic effects among Brazilian Bothrops spp. venoms",
journal="Toxicon: Journal of the International Society on Toxinology",
year="2013",
author="Campos, Lucas B. and Pucca, Manuela B. and Roncolato, Eduardo Crosara and Bertolini, Thaís Barboza and Netto, Joaquim C. and Barbosa, José E.",
volume="76",
number="",
pages="1-10",
abstract="In various types of snake venom, the major toxic components are proteinases and members of the phospholipase A2 family, although other enzymes also contribute to the toxicity. In this study, we evaluated the proteolytic, phospholipase, and L-amino acid oxidase activities in the venom of five Bothrops species-B. jararaca, B. jararacussu, B. moojeni, B. neuwiedi, and B. alternatus-all of which are used in the production of commercial antivenom, prepared in horses. The enzymatic activities of each species' venom were classified as high, moderate, or low. B. moojeni venom demonstrated the highest enzymatic activity profile, followed by the venom of B. neuwiedi, B. jararacussu, B. jararaca, and B. alternatus. To our knowledge, this is the first study to compare all of these enzymes from multiple species, which is significant in view of the activity of L-amino acid oxidase across Bothrops species.<p /> <p>Language: en</p>",
language="en",
issn="0041-0101",
doi="10.1016/j.toxicon.2013.08.063",
url="http://dx.doi.org/10.1016/j.toxicon.2013.08.063"
}