@article{ref1,
title="Elimination properties of the congener n-propanol",
journal="Blutalkohol",
year="1989",
author="Wehner, H. D. and Schieffer, M. C.",
volume="26",
number="1",
pages="28-41",
abstract="Intravenous injections of n-propanol (25 mg, 50 mg, 100 mg, 200 mg, 300 mg) provoke blood concentration curves having exponential shapes of dose dependent rate constants after a sufficiently long time (2 min). They have to be seen therefore as a result of a non-linear elimination process controlled by a Michaelis-Menten-kinetic. Using the Lineweaver-Burk-method the characteristic data of metabolism are determined, namely the maximal velocity of metabolizing beta PrOHmax as 2.5 mg/l min and the Michaelis-Menten-constant as 10 mg/l. An increase of the ethanol exposition causes a prolongation of the mean residence time of n-propanol in the body. This phenomenon is to be interpreted as the result of an inhibition of the n-propanol metabolism by ethanol. The inhibition constant KPrOHEtOH concerned with this process is determined experimentally and has a value of 0.1%.<p /> <p>Language: de</p>",
language="de",
issn="0006-5250",
doi="",
url="http://dx.doi.org/"
}