@article{ref1,
title="Double-blind placebo and active (caffeine) controlled study to examine the effects of the herbal nutritional supplement beverage "Wake up" on vigilance and function after lunch",
journal="Israel medical association journal : IMAJ",
year="2013",
author="Kassis, Ola and Katz, Neriel and Ravid, Sarit and Pillar, Giora",
volume="15",
number="8",
pages="419-423",
abstract="BACKGROUND: Post-lunch dip is a well-known phenomenon that results in a substantial deterioration in function and productivity after lunch. OBJECTIVES: To assess whether a new herbal-based potentially wake-promoting beverage is effective in counteracting somnolence and reduced post-lunch performance. METHODS: Thirty healthy volunteers were studied on three different days at the sleep clinic. On each visit they ate a standard lunch at noontime, followed by a drink of &quot;Wake up,&quot; 50 mg caffeine, or a placebo in a cross-over double-blind regimen. At 30 and 120 minutes post-drinking, they underwent a battery of tests to determine the effects of the beverage. These included: a) a subjective assessment of alertness and performance based on a visual analog scale, and b) objective function tests: the immediate word recall test, the digit symbol substitution test (DSST), and hemodynamic measurements. The results of the three visits were compared using one-way analysis of variance, with P < 0.05 considered statistically significant. RESULTS: In all performance tests, subjective vigilance and effectiveness assessment, both Wake up and caffeine were significantly superior to placebo 30 minutes after lunch. However, at 2 hours after lunch, performance had deteriorated in those who drank the caffeine-containing drink, while Wake up was superior to both caffeine and placebo. Blood pressure and pulse were higher 2 hours after caffeine ingestion, compared to both Wake up and placebo. CONCLUSIONS: These results suggest that a single dose of Wake up is effective in counteracting the somnolence and reduced performance during the post-lunch hours. In the current study it had no adverse hemodynamic consequences.<p /> <p>Language: en</p>",
language="en",
issn="1565-1088",
doi="",
url="http://dx.doi.org/"
}