@article{ref1,
title="Val158Met COMT polymorphism and risk of aggression in alcohol dependence",
journal="Addiction biology",
year="2013",
author="Soyka, Michael and Zill, Peter and Koller, Gabi and Samochowiec, Jerzy and Grzywacz, Anna and Preuss, Ulrich W.",
volume="20",
number="1",
pages="197-204",
abstract="Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism.<p /><p>Language: en</p>",
language="en",
issn="1355-6215",
doi="10.1111/adb.12098",
url="http://dx.doi.org/10.1111/adb.12098"
}