@article{ref1,
title="Risk of intracranial injury after minor head trauma in patients with pre-injury use of clopidogrel",
journal="American journal of emergency medicine",
year="2014",
author="Levine, Michael and Wyler, Benjamin and LoVecchio, Frank and Roque, Pedro and Raja, Ali S.",
volume="32",
number="1",
pages="71-74",
abstract="BACKGROUND: Clopidogrel is an adenosine diphosphate receptor antagonist. The risk of intracranial hemorrhage following minor head trauma in patients with pre-injury use of clopidogrel has not been fully determined. METHODS: This case-controlled study examined the effects of pre-injury use of clopidogrel in adult (age 14 years and older) patients with minor head trauma. RESULTS: During the study period, 1660 patients head computed tomography scans were performed in the emergency department, of which 658 met inclusion criteria. Intracranial hemorrhage was noted in 30% of patients on clopidogrel, compared with 2.2% of those patients without pre-injury use of clopidogrel. After performing a logistic regression analysis for confounders, the pre-injury use of clopidogrel was significantly associated with intracranial hemorrhage in this study population (OR 16.7; 95% CI 1.71-162.7). CONCLUSION: The use of clopidogrel is associated with a significantly increased risk of developing intracranial hemorrhage following minor trauma.<p /><p>Language: en</p>",
language="en",
issn="0735-6757",
doi="10.1016/j.ajem.2013.08.063",
url="http://dx.doi.org/10.1016/j.ajem.2013.08.063"
}