@article{ref1,
title="Evidence for parallel development of tolerance to the hyperactivating and discoordinating effects of ethanol",
journal="Psychopharmacology",
year="1977",
author="Hunt, G. P. and Overstreet, D. H.",
volume="55",
number="1",
pages="75-81",
abstract="Rats maintained on diets containing 6.5% ethanol or equicaloric sucrose solutions were challenged at weekly intervals with 1.5 or 2.0 g/kg ethanol or isotonic saline 14 h after withdrawal from the diet. Tolerance developed to both the hyperactivating (increased line crossings and time active) and discoordinating (disrupted rotarod performance) effects of the 1.5 g/kg dose of ethanol, but was less obvious with the 2.0 g/kg dose. Chlorpromazine (2.5 mg/kg) had a greater depressant effect in animals chronically treated with ethanol, suggesting that some alterations in the functioning of noradrenergic and/or dopaminergic systems may accompany chronic ethanol treatment. However, amphetamine and propranolol did not appear to affect ethanol- and sucrose-treated rats differently. The present studies have therefore shown a parallel development of tolerance to the discoordinating and hyperactivating effects of ethanol and have implicated an underlying noradrenergic and/or dopaminergic mechanism, although the precise nature of the mechanism has not been clarified.<p /><p>Language: en</p>",
language="en",
issn="0033-3158",
doi="",
url="http://dx.doi.org/"
}