@article{ref1,
title="Cimetidine-induced fatality: Confirmation by HPLC-MS",
journal="Journal (Canadian Society of Forensic Science)",
year="1992",
author="Alpe-Scott, M. D. and Lindsay, D.",
volume="25",
number="2",
pages="91-96",
abstract="Cimetidine, an histamine H2-receptor antagonist, used primarily in the treatment of various gastric disorders, has only been documented twice as the toxic agent in instances of fatal overdosage. A case is presented involving the suicidal death of a middle-aged woman. Routine toxicological analysis revealed therapeutic blood concentrations of diazepam, nordiazepam and Phenytoin with a large peak at carbon number 1930 unidentified by gas chromatography-mass spectrometry (GC-MS). Cimetidine was confirmed by high performance liquid chromatrography-mass spectrometry (HPLC-MS) analysis. Isocratic ion-pairing reversed phase HPLC was used to quantify Cimetidine and the following results obtained: blood (780 μg/mL), urine (19000/μg/mL), liver (20000 μg/g) and gastric contents (9.5 g of Cimetidine in 170 g).<p />",
language="en",
issn="0008-5030",
doi="10.1080/00085030.1992.10757004",
url="http://dx.doi.org/10.1080/00085030.1992.10757004"
}