@article{ref1,
title="Why proof of safety is much more difficult than proof of hazard",
journal="Biometrics",
year="1985",
author="Bross, I. D.",
volume="41",
number="3",
pages="785-793",
abstract="On the basis of simple, generally accepted biostatistical and public health principles, it is shown that for environmental health hazards a proof of safety is much more difficult than a proof of hazard. The effective sample sizes required for proof of safety are orders of magnitude greater than what is feasible in biostatistical-epidemiological studies. Although many assurances of safety &quot;in the name of science&quot; have been issued by government agencies and others, few if any of these assurances are statistically valid.<p /> <p>Language: en</p>",
language="en",
issn="0006-341X",
doi="",
url="http://dx.doi.org/"
}