@article{ref1,
title="The effect of trazodone on standardized field sobriety tests",
journal="Pharmacotherapy",
year="2013",
author="Ip, Eric J. and Bui, Quang V. and Barnett, Mitchell J. and Kazani, Amin and Wright, Roger and Serino, Melissa J. and Perry, Paul J.",
volume="33",
number="4",
pages="369-374",
abstract="STUDY OBJECTIVE: To evaluate the effects of a single dose of trazodone on the standardized field sobriety test (SFST). DESIGN: A randomized, double-blinded, repeated-measures study. PARTICIPANTS: Forty-five healthy adult subjects. SETTING: University campus. MEASUREMENTS AND MAIN RESULTS: The SFST consists of the horizontal gaze nystagmus, walk-and-turn, and one-leg stand tests. Subjects were administered a baseline SFST and at 2 hours after the administration of either trazodone 100 mg (30 subjects) or acetaminophen 650 mg (15 subjects). At 2 hours post drug administration, there were no statistical differences in failure rates between the trazodone and acetaminophen groups (53.3% vs 20.0%, p=0.054). However, the trazodone group exhibited more impairment clues within the individual tests of the SFST than the acetaminophen group. CONCLUSIONS: A one-time dose of trazodone 100 mg does not result in an increased SFST failure rate at 2 hours postdosing compared to acetaminophen 650 mg. However, the number of individual impairment clues detected is increased with trazodone. Trazodone 100 mg may cause cognitive driving impairment.<p /> <p>Language: en</p>",
language="en",
issn="0277-0008",
doi="10.1002/phar.1210",
url="http://dx.doi.org/10.1002/phar.1210"
}