@article{ref1,
title="Deliberate self-overdose with propranolol. Changes in serum levels (author's transl)",
journal="Nouvelle Presse Medicale",
year="1978",
author="Ducret, F. and Zech, P. and Perrot, D. and Moskovtchenko, J. F. and Traeger, J.",
volume="7",
number="1",
pages="27-28",
abstract="Suicidal attempt using beta-blockers are rare. Overdose by the ingestion of a large number of tablets rarely exceeds the high therapeutic doses suggested for the treatment of certain resistant cases of hypertension. The case described is that of a 65-year-old patient who took 800 mg of propanolol. Observation of plama levels showed that the half-life propanolol in the case of overdose is prolonged: 8.6 hours in this case, with a maximum plasma level of 1536 ng/ml. Plasma renin activity levels were low during the phase of intoxication and showed evidence of a rebound effect at its end. Treatment is above all that of the circulatory insufficiency produced: isopropylnoradrenaline or glucagon. Indications for extra-renal dialysis should take into account knowledge concerning the pharmacokinetics of these drugs and their prolonged physiological action.<p /><p>Language: fr</p>",
language="fr",
issn="0301-1518",
doi="",
url="http://dx.doi.org/"
}