@article{ref1,
title="Frontal white matter damage impairs response inhibition in children following traumatic brain injury",
journal="Archives of clinical neuropsychology",
year="2014",
author="Lipszyc, Jonathan and Levin, Harvey and Hanten, Gerri and Hunter, Jill and Dennis, Maureen and Schachar, Russell",
volume="29",
number="3",
pages="289-299",
abstract="Inhibition, the ability to suppress inappropriate cognitions or behaviors, can be measured using computer tasks and questionnaires. Inhibition depends on the frontal cortex, but the role of the underlying white matter (WM) is unclear. We assessed the specific impact of frontal WM damage on inhibition in 29 children with moderate-to-severe traumatic brain injury (15 with and 14 without frontal WM damage), 21 children with orthopedic injury, and 29 population controls. We used the Stop Signal Task to measure response inhibition, the Behavior Rating Inventory of Executive Function to assess everyday inhibition, and T2 fluid-attenuated inversion recovery magnetic resonance imaging to identify lesions. Children with frontal WM damage had impaired response inhibition compared with all other groups and poorer everyday inhibition than the orthopedic injury group. Frontal WM lesions most often affected the superior frontal gyrus. These results provide evidence for the critical role of frontal WM in inhibition.<p /> <p>Language: en</p>",
language="en",
issn="0887-6177",
doi="10.1093/arclin/acu004",
url="http://dx.doi.org/10.1093/arclin/acu004"
}