@article{ref1,
title="A predictive model of early mortality in trauma patients",
journal="American journal of surgery",
year="2014",
author="Hampton, David A. and Lee, Tim H. and Diggs, Brian S. and McCully, Sean P. and Schreiber, Martin A.",
volume="207",
number="5",
pages="642-7; discussion 647",
abstract="BACKGROUND: Rapid thrombelastography (rTEG) is a real-time whole-blood viscoelastic coagulation assay. We hypothesized that admission rTEG and clinical data are independent predictors of trauma-related mortality. <br><br>METHODS: Prospective observational data (patient demographics, admission vital signs, laboratory studies, and injury characteristics) from trauma patients enrolled within 6 hours of injury were collected. Mann-Whitney U test and analysis of variance test assessed significance (P ≤.05). Logistic regression analyses determined the association of the studied variables with 24-hour mortality. <br><br>RESULTS: Seven hundred ninety-five trauma patients were enrolled, of which 55 died within 24 hours of admission. Admission variables which independently predicted 24-hour mortality were as follows: Glasgow Coma Scale ≤8, hemoglobin <11 g/dL, international normalized ratio >1.5, Ly30 >8%, and penetrating injury (P <.05). This 5-variable model's area under the receiver operator characteristic curve was.88. The Hosmer-Lemeshow goodness-of-fit test was.90. <br><br>CONCLUSIONS: This 5-variable model provides a rapid prediction of 24-hour mortality. The inclusion of rTEG Ly30 demonstrates the association of fibrinolysis with outcome and may support the early use of antifibrinolytic therapies.<p /> <p>Language: en</p>",
language="en",
issn="0002-9610",
doi="10.1016/j.amjsurg.2013.12.009",
url="http://dx.doi.org/10.1016/j.amjsurg.2013.12.009"
}