@article{ref1,
title="A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States",
journal="Expert review of clinical pharmacology",
year="2014",
author="Blieden, Marissa and Paramore, L. Clark and Shah, Dhvani and Ben-Joseph, Rami",
volume="7",
number="3",
pages="341-348",
abstract="Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity. Recent FDA and CMS decisions serve to limit and monitor exposure to high-dose acetaminophen. This literature review aims to describe the exposure to and consequences of high-dose acetaminophen among chronic pain patients in the US. Each year in the US, approximately 6% of adults are prescribed acetaminophen doses of more than 4 g/day and 30,000 patients are hospitalized for acetaminophen toxicity. Up to half of acetaminophen overdoses are unintentional, largely related to opioid-acetaminophen combinations and attempts to achieve better symptom relief. Liver injury occurs in 17% of adults with unintentional acetaminophen overdose.<p /> <p>Language: en</p>",
language="en",
issn="1751-2433",
doi="10.1586/17512433.2014.904744",
url="http://dx.doi.org/10.1586/17512433.2014.904744"
}