@article{ref1,
title="Ethanol: modifications of acute intoxication by divalent cations",
journal="Science",
year="1978",
author="Erickson, C. K. and Tyler, T. D. and Harris, R. A.",
volume="199",
number="4334",
pages="1219-1221",
abstract="Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="",
url="http://dx.doi.org/"
}