@article{ref1,
title="Contribution of skeletal muscle protein in elevated rates of whole body protein catabolism in trauma patients",
journal="American journal of clinical nutrition",
year="1981",
author="Long, C. L. and Birkhahn, R. H. and Geiger, J. W. and Blakemore, W. S.",
volume="34",
number="6",
pages="1087-1093",
abstract="Whole body protein breakdown using 15N and skeletal muscle protein breakdown from urinary 3-methylhistidine were measured simultaneously in seven skeletal trauma and eight normal subjects on a standard hypocaloric, protein free diet. The trauma group had a 31% greater resting metabolic energy expenditure than controls. The control males lost 3.73 mumol/kg/day of 3-methylhistidine which suggested a protein breakdown rate of 0.89 g P/kg/day. The control females lost 2.46 mumol/kg/day of 3-methylhistidine or a breakdown rate of 0.58 g P/kg/day. These parameters were 187% greater for males and 163% greater for females in the trauma group. The measured whole body protein breakdown rates were 3.64 g P/kg/day for the control males and 2.69 for females. Skeletal trauma increased both by 73%. Skeletal trauma raised the muscle contribution to the whole body breakdown rate from 24.4 to 40.4% for men and from 21.6 to 33.0% for women. This disproportionate increase in muscle protein breakdown is consistent with muscle protein metabolism being most seriously affected by severe injury.<p /><p>Language: en</p>",
language="en",
issn="0002-9165",
doi="",
url="http://dx.doi.org/"
}