@article{ref1,
title="Mustard Gas Inhalation Injury: Therapeutic Strategy",
journal="International journal of toxicology",
year="2014",
author="Keyser, Brian M. and Andres, Devon K. and Holmes, Wesley W. and Paradiso, Danielle and Appell, Ashley and Letukas, Valerie A. and Benton, Betty and Clark, Offie E. and Gao, Xiugong and Ray, Prabhati and Anderson, Dana R. and Ray, Radharaman",
volume="33",
number="4",
pages="271-281",
abstract="Mustard gas (sulfur mustard [SM], bis-[2-chloroethyl] sulfide) is a vesicating chemical warfare agent and a potential chemical terrorism agent. Exposure of SM causes debilitating skin blisters (vesication) and injury to the eyes and the respiratory tract; of these, the respiratory injury, if severe, may even be fatal. Therefore, developing an effective therapeutic strategy to protect against SM-induced respiratory injury is an urgent priority of not only the US military but also the civilian antiterrorism agencies, for example, the Homeland Security. Toward developing a respiratory medical countermeasure for SM, four different classes of therapeutic compounds have been evaluated in the past: anti-inflammatory compounds, antioxidants, protease inhibitors and antiapoptotic compounds. This review examines all of these different options; however, it suggests that preventing cell death by inhibiting apoptosis seems to be a compelling strategy but possibly dependent on adjunct therapies using the other drugs, that is, anti-inflammatory, antioxidant, and protease inhibitor compounds.<p /><p>Language: en</p>",
language="en",
issn="1091-5818",
doi="10.1177/1091581814532959",
url="http://dx.doi.org/10.1177/1091581814532959"
}