@article{ref1,
title="Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam",
journal="Natural product research",
year="2014",
author="Gorantla, Jaggaiah N. and Vellekkatt, Jamsheena and Nath, Lekshmi R. and Anto, Ruby John and Lankalapalli, Ravi S.",
volume="28",
number="18",
pages="1507-1512",
abstract="We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.<p /> <p>Language: en</p>",
language="en",
issn="1478-6419",
doi="10.1080/14786419.2014.913242",
url="http://dx.doi.org/10.1080/14786419.2014.913242"
}