@article{ref1,
title="Determination of serum crimidine in a patient who ingested a "lightening rodenticide"",
journal="Acta clinica Belgica",
year="2002",
author="Besnard, T. and Sadeg, N. and Ricart, N. and Richecœur, J. and Nisse, P. and Vinner, E. and Houdret, N. and Humbert, L. and Lhermitte, M.",
volume="57",
number="Suppl 1",
pages="8-11",
abstract="Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hypertonic coma and convulsions. Toxic level in human is about 5 mg/Kg. An intoxication case is reported. Five serums collected at different times were analyzed with HPLC/ ES/MS. Crimidine was extracted with ethylacetate with recovery over 80 %. Linearity was up to 800 μg/L. LOQ and LOD were 0.5 and 0.3 μg/L respectively. The coefficients of variation were less than 10 % for repeatability and reproductibility. Serum levels varied from 368 μg/L for H0 to 64 μg/L for H10 and elimination of crimidine was linear in time.<p /> <p>Language: en</p>",
language="en",
issn="1784-3286",
doi="10.1179/acb.2002.069",
url="http://dx.doi.org/10.1179/acb.2002.069"
}