@article{ref1,
title="Neurodegenerative disorder masquerading as psychosis in a forensic psychiatry setting",
journal="BMJ case reports",
year="2014",
author="Sommerlad, Andrew and Lee, James and Warren, Jason and Price, Gary",
volume="2014",
number="ePub",
pages="ePub-ePub",
abstract="A man presenting in his 50s, following conviction for a non-violent crime, to forensic psychiatric services, and then to a neuropsychiatry service with an unusual presentation of psychosis: second person auditory hallucinations, grandiose delusions and somatic delusions. Detailed collateral and family history revealed a background of progressive cognitive deficit and a family history of motor neuron disease. MRI of the brain revealed asymmetrical parieto-occipital volume loss and genetic testing demonstrated a pathogenic expansion of the chromosome 9 open reading frame 72 (C9ORF72) gene consistent with familial frontotemporal dementia caused by a hexanucleotide repeat expansion at C9ORF72, a recently discovered cause of familial frontotemporal dementia/motor neuron disease. This form of frontotemporal dementia should be considered as an important potential differential diagnosis for patients presenting with psychotic symptoms in later life, in whom a detailed family history and thorough cognitive assessment is essential.<p /> <p>Language: en</p>",
language="en",
issn="1757-790X",
doi="10.1136/bcr-2013-203458",
url="http://dx.doi.org/10.1136/bcr-2013-203458"
}