@article{ref1,
title="Does clozapine promote employability and reduce offending among mentally disordered offenders?",
journal="Canadian journal of psychiatry, The",
year="2010",
author="Balbuena, Lloyd and Mela, Mansfield and Wong, Stephen and Gu, Deqiang and Adelugba, Olajide O. and Tempier, Raymond",
volume="55",
number="1",
pages="50-56",
abstract="OBJECTIVE: To compare employment pay, count of infractions, and clinical symptoms in psychiatric inmates treated with clozapine or other antipsychotics after 6 months of treatment. <br><br>METHODS: Clinical charts and institutional offence records of psychiatric inmates (n = 98), comprised of those on clozapine (n = 65) and on other antipsychotics (n = 33), were reviewed at baseline and after 6 months of treatment. The outcome measures used were Brief Psychiatric Rating Scale (BPRS) scores, employment pay, medication compliance, and the frequency of institutional offences. A binary logistic regression model was used to analyze a categorical change in pay variable, while a negative binomial model was used to analyze the frequency of infractions. <br><br>RESULTS: Treatment with clozapine was associated with greater odds of a pay increase (OR = 3.13; 95% CI 1.3 to 7.53, P = 0.01). However, patients on other antipsychotics had a more favourable improvement in BPRS (F = 5.44, df = 1,57, P = 0.02). Patients on other antipsychotics also had a higher count of posttreatment offences (Incidence Rate Ratio = 2.22; 95% CI 1.11 to 4.41, P = 0.02). <br><br>CONCLUSION: Clozapine probably has a favourable effect on inmate behaviour and institutional adjustment. This effect can last up to 36 months after the initial dose.<p /><p>Language: en</p>",
language="en",
issn="0706-7437",
doi="",
url="http://dx.doi.org/"
}